Central giant cell granuloma cgcg is an uncommon benign intraosseous lesion of the jaw, found predominantly in children and young adults below 30 years of age. Central giant cell granuloma of the jaws springerlink. Central giant cell granuloma cgcg, formerly called giant cell reparative granuloma, is a nonneoplastic proliferative lesion of an unknown aetiology. Kruselosler b, diallo r, gaertner spindle cell recruits monocytes and c, mishcke kl, joos u, kleinheinz j. Historically, the lesion has been referred to by numerous terms, including myeloid sarcoma, tumor of myeloplaxus, osteoblastoclastoma, and osteoclastoma, 2, 5 gct is a relatively common skeletal tumor, accounting for 4%9. A 38 year demographic study of central and peripheral giant. Central giant cell granuloma is an uncommon benign intraosseus lesion of jaws. For the previously reported cases in one female and three males, the mean age at presentation was 30 years. Treatment of central giant cell granuloma in children with. Controversy exists regarding the histogenesis of this lesion. Central giant cell granuloma and fibrous dysplasia occurring in the. Up to now, there are no reliable histologic or molecular methods to differentiate aggressive from nonaggressive central giant cell granuloma of the jaw. Central giant cell granuloma of the jaws is comprised of two types namely aggressive and nonaggressive.
The purpose of this study was to determine the ct characteristics and describe possible mr imaging features of gcg of the craniofacial bones. An 8yearold boy presented himself complaining of a painless swelling in the left maxilla that had started 1 year. In 1953, jaffe was the first to describe these lesions as a giant cell reparative granuloma of the jawbones, and in 1971, thanks to pindborg and kramer, it was included in the current nomenclature. Dec 28, 2019 central giant cell granulomas of the condyle are rare. Radiographically, it presents as a distinct delineated bony pathology with a. None declared introduction central giant cell granuloma cgcg is defined by the world health organization as an intraosseous lesion consisting of cellular fibrous tissue that contains multiple. Peripheral giant cell granuloma pgcg is a common reactive gingival lesion that histologically resembles the central giant cell granuloma, and is a central lesion of the jaws. Giant cell granuloma of the respira tory tract or central giant cell granuloma. In the craniofacial skeleton, gcg can be central or peripheral. Jun 02, 2020 the central giant cell granuloma cgcg of the jaws is a rare benign tumour of the mandible lower jaw and the maxilla upper jaw characterized by destruction of the bone, loss of symmetry of the face and displacement of teeth and tooth germs, especially in younger patients. Pdf central giant cell granuloma aggresive of the jaws. Giant cell tumor gct of bone was first described by sir astley cooper in 1818, 1. A case report of a peripheral giant cell granuloma in a. Giant cell reparative granuloma of the nasal cavity.
Radiologic features of central giant cell granuloma of the. The central giant cell granuloma is an uncommon, benign and proliferative pathological condition accounting for less than 7% of all benign lesions of the jaws whose etiology is not clearly explained. Central giant cell granuloma aggresive of the jaws. Noonan syndrome associated with central giant cell granuloma. Occasionally, central giant cell granuloma like lesions may be seen in association with hyperparathyroidism. Central giant cell granuloma is widely considered to be a. Traditional treatment has been local curettage, although aggressive subtypes have a high tendency to recur.
The aim of this prospective study was to evaluate the outcome of treatment of a group of 17 patients with central giant cell granuloma cgcg who were treated in our clinic. It occurs mainly in young people between the ages of 10 and 20 years, but cases have been reported both earlier and later 1. Central giant cell granuloma of the jaw is considered a nonneoplastic lesion. The radiologic features of central giant cell granuloma cgcg have not been clearly. This paper aims to report a case in which central giant cell granuloma cgcg mimicked a periapical lesion of endodontic origin. Casereport munzenmayer j1, tapia p2, zeballos j2, martinez a3, compan a4, urra a5, spencer ml6 summary this case report describes a 19yearold female patient with a central giant cell granuloma in the left mandibular condyle, treated with en bloc resection and reconstruction with fibula graft. Imaging of giant cell tumor and giant cell reparative. Central giant cell granuloma of the mandible american. Treatments for condylar lesions range from curettage to lesion resection 6. It is a benign lesion that sometimes can be an aggressive osteolytic proliferation consisting of fibrous tissue with osteoclastlike giant cells. Central giant cell granuloma cgcg is a non neoplasic lesion of unknown etiology.
A course of in phosphonates have been used to treat giant cell tralesional corticosteroid injections was discussed tumours and. Central giantcell granuloma cgcg is a localised benign condition of the jaws. Bilateral central giant cell granuloma of the mandibular. Radiologic features of central giant cell granuloma of the jaws. Cyclin d1 protein overexpression may be involved in the formation of the giant cells and the pathogenesis of central giant cell granuloma 3. Central giant cell granuloma mimicking a periapical lesion of. Extensive aggressive central giant cell granuloma of the mandible. Nonsurgical management of central giant cell granuloma. Mar 01, 1993 central giant cell granuloma report of a case brad,1. The central giant cell granuloma is an uncommon lesion, accounting for less than 7% of all benign jaw lesions. Central giant cell granuloma of the jaw is considered a. Central giant cell granuloma, benign jaw tumor, molar, recurrent pericoronitis, multinucleated giant cells.
Giant cell reparative granulomas gcrgs are benign osteolytic nonneoplastic granulomatous lesions of bone which occur most commonly in the maxilla and mandible in children and young adults. Apr 17, 2015 central giant cell granuloma was 1st described in jaws by jaffe 1953. The case reported here resembled a wide variety of conditions that led to a misdiagnosis both on clinical and radiographic examinations but was histopathologically diagnosed as cgcg. A recurrent central giant cell granuloma in a young.
Evaluation of cyclin d1 expression in aggressive and. Pdf central giant cell granuloma of mandible mohit. Intrabone dense connective tissue with oval spindle cells and giant cells, indicating a fibroma granuloma central giant cell. The central giant cell granuloma cgcg is a benign intraosseous proliferative lesion that occurs almost exclusively in the jaws. World health organization who as a localized and benign but sometimes aggressive lesion. Pdf central giant cell granuloma is an uncommon, benign, and proliferative lesion whose etiology is not defined. Clinically and radiologically, a differentiation between aggressive and nonaggressive lesions can be made. Cgcg treatment and management is challenging for clinicians.
Pdf treatment of a central giant cell granuloma with. Radiographically, it presents as a distinct delineated bony pathology with a loss of lamina dura around. Central giant cell granuloma cgcg is an uncommon locally destructive, but benign lesion that occurs in the craniofacial region especially in jaw bones. Medications that were developed for the treatment of giant cell tumor of bone and bone resorption from metastatic skeletal disease have shown some success in the treatment of cgcg. Pdf cd68 expression in central giant cell granuloma. Jan 05, 2019 central giant cell granuloma introduction. Its differential diagnosis includes tumours, cysts and tumourlike conditions of the preauricular area 8.
Dec 01, 2014 in recent years, the treatment of central giant cell granuloma cgcg has become focused on the inhibition of osteoclast differentiation and proliferation. Central giant cell granuloma cgcg is a benign intraosseous lesion that occurs in long bones. Central giant cell granuloma of the hard palate hector n. Pdf on jun 7, 2019, nilotpol kashyap and others published central giant cell granuloma find, read and cite all the research you need on. It occurs more frequent in the fifth and sixth decades of life with a slight female predilection 3. Kaffe i1, ardekian l, taicher s, littner mm, buchner a. The radiologic features of central giant cell granuloma cgcg have not been clearly defined, and conflicting descriptions appear in the literature.
Case presentation this report presents the treatment and management of recurrent, aggressive cgcg after surgical resection. Jan 20, 2021 central giant cell granuloma cgcg is one of the most intriguing lesions of the jaws and its nature has not yet been fully elucidated. Central giant cell granuloma cgcg is described by the. Central giant cell granuloma central giant cell granuloma is an uncommon benign bony lesion that occurs in the mandible and maxilla and accounts for approximately 7% of all benign tumours of the.
Radiologic features of central giant cell granuloma of the jaws oral. Cgcg is described as a benign lesion affecting the mandible and maxilla that consists of a massive fibrohistiocytic prolife ration. In cases of aggressive cgcg of the maxilla, effective personalized therapies are worth understanding. Recently use of interferon alfa has been reported as an additional treatment modality on the basis of an antiangiogenic mode of action 3. Ct and mr imaging of giant cell granuloma of the craniofacial. Central giant cell granuloma cgcg is an intraosseous lesion consisting of fibrous cellular tissue that contains multiple foci of hemorrhage, multinucleated giant cells, and occasional trabeculae of woven bone. The tumor is not a true granuloma and is not having reparative process. In 1953, jaffe described it as reparative granuloma of jaw bones. Central giant cell granuloma cgcg is a benign bone lesion which can be locally aggressive or may be asymptomatic in nature. Medical therapy is indicated when surgery is associated with increased morbidity or in adjuvant setting to decrease recurrence. An aggressive central giant cell granuloma in a pediatric. Wood nk, goaz pwdifferential diagnosis of oral lesions.
Central giant cell granuloma is a benign, non odontogenic lesion accounting for fewer than 7% of all benign tumors of the jaws. In nearly 50% of the cases the lesion is located in the posterior area of the jaws, that is, the molar, ramus, and. Radiotherapy for recurrent central giant cell granuloma. Gcrg is an uncommon benign lesion that is most commonly found in the mandible and maxilla. Central giant cell granuloma cgcg is a benign lesion of the jaws with an unknown etiology. Its etiology is unknown and its biological behavior is poorly understood. It is twice as common in females and is more likely to occur before age 30.
We report an unusual case of giant cell reparative granuloma gcrg arising in the nasal cavity of a 7yearold girl. Jan 01, 2020 central giant cell granuloma may have a genetic etiology. Central giant cell granuloma cgcg is an uncommon benign intraosseous lesion of the jaw, found predominantly in children and young adults. Abstract this paper aims to report a case in which central giant cell granuloma cgcg mimicked a periapical lesion of endodontic origin. This study analyzes the radiologic and clinical features of 80 cases of cgcg. Central giant cell granulomas are more common in the anterior mandible, often crossing the midline and causing painless swellings. After informed consent was obtained, the patient underwent. Central giant cell granuloma cgcg, formerly called giant cell reparative granuloma, is a nonneoplastic proliferative lesion of unknown etiology. This tumor is histopathologically and behaviourally identical to the benign giant cell tumor of long bones. Jul 18, 2019 background central giant cell granulomas are benign tumours of the mandible, presenting in children and young adults. Nonsurgical management of central giant cell granuloma with. It is an uncommon tumor in jaws, its etiology and pathogenesis is unknown. Management of central giant cell granuloma with subcutaneous. A recurrent central giant cell granuloma in a young patient and.
Divided into non and aggressive subtypes, the aggressive subtype is relatively rare and can occasionally progress rapidly, resulting in significant morbidity. Combination therapies for the treatment of recurrent central giant. The central giant cell granuloma cgcg of the jaws is a rare benign tumour of the mandible lower jaw and the maxilla upper jaw characterized by destruction of the bone, loss of symmetry of the face and displacement of teeth and tooth germs, especially in younger patients. An intraosseus destructive lesion of the anterior mandible and maxilla in which larger lesion expand the cortical plates, causes movement of. The aim of this prospective study was to evaluate the outcome of treatment of a group of 17 patients with central giant cell granuloma cgcg who. Apr 23, 2008 we report a case of noonan syndrome associated with central giant cell granuloma. Central giant cell granuloma cgcg is a nonneoplastic benign bony lesion of unknown origin. Jan 16, 2021 central giant cell granuloma cgcg of the jaws is a wellrecognized clinical entity of unknown etiology. Central giant cell granuloma of the mandible requiring multiple. This condition is a slowgrowing, asymptomatic lesion that usually affects children and young adults, predominantly females. Giant cell granuloma gcg is an uncommon, benign, proliferative, intraosseous lesion representing dec 28, 2019. Alternative treatments and therapies in central giant cell.
Peripheral giant cell granulomas are more common, arising from periosteum or. But the term reparative is obsolete, as cgcg causes the destruction of involved bones. Denosumab for the management of central giant cell. Denosumab for the management of central giant cell granuloma. Surgically treated central giant cell granuloma in six. The central giant cell granuloma cgcg is an uncommon benign bony lesion that accounts for less than 7% of all benign lesions of the jaws in toothbearing areas.
Giant cell granuloma gcg is an uncommon, benign, proliferative, intraosseous lesion representing jul 19, 2019 background central giant cell granuloma cgcg is a rare, nonneoplastic, benign lesion that exhibits expansive and osteolytic biological behavior. Central giant cell granuloma of the maxilla bmj case reports. The central giant cell granuloma cgcg presents as a benign, painless, slowgrowing swelling of the jaw. He also had various malformations such as short stature, webbed neck, pectus excavatum, cubitus valgus, pulmonary valve stenosis and patent foramen ovale, a. Surgically treated central giant cell granuloma in sixyear. Pdf central giant cell granuloma of mandible mohit sharma.
The term giant cell reparative granuloma of the jaws was proferred by jaffe 1953 to distinguish the reactive lesion commonly occurring in the jaws from the giant. Clinicalpathological considerations and report of a case. Download introductioncentral giant cell tumors of the jaws are nonodontogenic, benign but aggressively destructive osteolytic lesions. Radiographically, it presents as a distinct delineated bony pathology with a loss of lamina dura around teeth.
Case presentation we present a case of an aggressive central giant cell granuloma cgcg in a six yearold female. Oct 21, 2020 central giant cell granuloma cgcg is a benign but locally aggressive intraosseous lesion of the mandible. Central giant cell granuloma of the mandibular condyle. A group of 17 patients with cgcg were treated in the clinic of oral and maxillofacial surgery of the g. Who has defined it as an intraosseous lesion consisting of cellular and fibrous tissue that contains multiple foci of hemorrhage, aggregation of multinucleated giant cells and occasionally trabaculae of woven bone 3. N11siry and umvhrsiiy oh thxas htaltil scibncli clntkr at san antonio the central giant cell granuloma is a tumor that has great potential for the displacement of teeth and the development of a facial deformity.
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